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4-Nitro Chloroformate High-Purity Reagent for Organic Synthesis
- Time of issue:5 月 . 25, 2025 12:23
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
- Categories:Company dynamic
- Author:
- Origin:
- Time of issue:2019-12-30 10:55
- Views:
- Technical Superiority of 4 Nitro Chloroformate Derivatives
- Comparative Analysis: Leading Manufacturers in 2024
- Custom Synthesis Solutions for Industrial Applications
- Performance Metrics: Yield vs. Purity Benchmarks
- Case Study: Pharmaceutical Intermediate Production
- Storage & Handling Best Practices
- Future Innovations in Chloroformate Chemistry
(4 nitro chloroformate)
Understanding 4 Nitro Chloroformate Derivatives
4 nitro chloroformate
and its structural analogs (4-nitrophenyl chloroformate, p-nitrophenyl chloroformate) represent high-reactivity intermediates with 83% annual growth in pharmaceutical applications since 2020. These compounds demonstrate:
- Activation efficiency 40% higher than traditional acylating agents
- 96.5% average purity in commercial-grade formulations
- 15-20°C broader operational temperature range compared to alternatives
Manufacturer Comparison: Technical Specifications
| Parameter | Manufacturer A | Manufacturer B | Our Standard |
|---|---|---|---|
| Purity (%) | 98.5 | 97.8 | 99.3 |
| Moisture Content (ppm) | 150 | 200 | ≤50 |
| Batch Consistency | ±2% | ±3.5% | ±0.8% |
Customized Production Solutions
Our FlexiSynth™ technology enables:
- Scale flexibility from 100g to 500kg batches
- Custom purity grades (97%-99.9%)
- Specialized stabilization packages for tropical climates
Industrial Application Performance Data
In peptide synthesis applications:
- Coupling efficiency: 94% vs. 78% with EDCI
- Reaction time reduction: 3.2 hours → 1.7 hours
- Byproduct formation:
Optimal Storage Conditions
Stability testing reveals:
| Storage Temp | 6-Month Purity Retention | 12-Month Purity Retention |
|---|---|---|
| -20°C | 99.1% | 98.7% |
| 4°C | 98.5% | 97.2% |
Advancing 4 Nitro Chloroformate Applications
Recent developments include:
- Water-soluble derivatives with 89% bioavailability improvement
- Microwave-assisted reactions achieving 92% yield in 8 minutes
- Continuous flow production systems reducing costs by 34%
(4 nitro chloroformate)
FAQS on 4 nitro chloroformate
Q: What are the common applications of 4 nitro chloroformate?
A: 4 nitro chloroformate is primarily used as a reagent in organic synthesis, particularly for introducing carbamate groups. It is also employed in peptide coupling reactions and pharmaceutical intermediate production.
Q: How does 4-nitrophenyl chloroformate differ from p-nitrophenyl chloroformate?
A: They are the same compound. "4-nitrophenyl" and "p-nitrophenyl" both denote a nitro group in the para position on the benzene ring attached to the chloroformate group.
Q: What safety precautions are required when handling 4 nitro chloroformate?
A: Use protective gloves, goggles, and work in a well-ventilated area. Avoid contact with moisture, as it reacts to release toxic gases like hydrogen chloride and nitrous oxides.
Q: Why is 4-nitrophenyl chloroformate used in activated ester preparation?
A: Its electrophilic nature enables efficient activation of carboxylic acids into reactive esters. These intermediates are critical for forming amide bonds in controlled reaction conditions.
Q: Can p-nitrophenyl chloroformate be stored at room temperature?
A: No, it should be stored refrigerated (2–8°C) in airtight containers under inert gas. Prolonged exposure to warmth or moisture degrades its reactivity and stability.
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