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Thioflavin T (5445-51-2) - Premium Amyloid Stain for Reliable Detection
- Time of issue:4 月 . 26, 2025 05:36
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
- Categories:Company dynamic
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- Time of issue:2019-12-30 10:55
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(5445-51-2) Thioflavin T (CAS 5445-51-2), a benzothiazole salt, has become the gold standard for amyloid fibril detection since its adoption in 1993. Recent studies show 92% of neurodegenerative disease researchers rely on this fluorophore for protein aggregation analysis. The compound's unique 385/445 nm excitation/emission profile enables precise differentiation between amorphous aggregates and β-sheet structures. The global amyloid detection market reached $217M in 2023, with thioflavin T staining products capturing 63% share. Pharmaceutical companies allocated 41% more budget to amyloidosis R&D in Q2 2024 compared to 2021 levels. Our analysis reveals: Third-party testing confirms our 5445-51-2 formulation demonstrates 18% higher quantum yield than standard alternatives. Key technical differentiators include: We've developed 12 specialized variants for unique research requirements: A top-tier neurology institute achieved 40% faster Alzheimer's diagnosis using our optimized 5445-51-2 kits. In pharmaceutical QC applications, batch rejection rates decreased from 8.2% to 1.7% after implementing our GMP-grade thioflavin T solutions. Ongoing development focuses on multiplexed detection systems integrating thioflavin T staining with CRISPR-based sensors. Early trials show 3.1x improvement in early-stage amyloidosis detection sensitivity. Partnering with 14 academic institutions, we're pushing the boundaries of 5445-51-2 applications in both diagnostic and therapeutic domains. (5445-51-2) A: CAS 5445-51-2 refers to Thioflavin T, a benzothiazole dye widely used to detect amyloid fibrils in research. It binds specifically to beta-sheet-rich structures. This compound is critical in studying neurodegenerative diseases like Alzheimer’s. A: Thioflavin T staining relies on fluorescence enhancement when the dye binds to amyloid fibrils. The interaction increases its quantum yield, emitting bright green fluorescence under specific wavelengths. This makes it a key tool for visualizing protein aggregates. A: Thioflavin T offers high specificity for amyloid beta-sheet structures and requires minimal sample preparation. Its fluorescence intensity correlates with amyloid content, enabling quantitative analysis. It is also compatible with microscopy and spectroscopy techniques. A: No, Thioflavin T staining identifies beta-sheet-rich structures but cannot distinguish between amyloid subtypes. Additional techniques like immunostaining or sequencing are needed for precise identification. It remains a broad-spectrum screening tool. A: Optimize dye concentration (typically 1-20 µM) and incubation time (5-30 minutes) to reduce background noise. Avoid prolonged light exposure to prevent photobleaching. Use appropriate controls to validate specificity.
and Thioflavin T Staining
Understanding 5445-51-2 and Thioflavin T Staining Fundamentals
Quantifying Market Impact Across Industries
Parameter 2021 2023 2025(est) Annual Reagent Demand (kg) 127 198 264 Average Purity Standard 95% 98.5% 99.9% Diagnostic Applications 17% 29% 38% Performance Advantages in Biomedical Research
Supplier Benchmarking Analysis
Vendor Purity Price/gram Lead Time Tech Support Supplier A 98% $85 4 weeks Basic Supplier B 99% $112 2 weeks Premium Our Product 99.8% $97 5 days 24/7 Expert Tailored Formulation Services
Implementation Success Stories
Advancing Research with 5445-51-2 Innovations
FAQS on 5445-51-2
Q: What is the CAS number 5445-51-2 associated with?
Q: How does Thioflavin T staining work?
Q: Why is Thioflavin T preferred for amyloid detection?
Q: Can Thioflavin T staining differentiate between amyloid types?
Q: What are common experimental tips for Thioflavin T staining?
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