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Thioflavin T (5445-51-2) - Premium Amyloid Stain for Reliable Detection
- Time of issue:Apr . 26, 2025 05:36
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
- Categories:Company dynamic
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- Time of issue:2019-12-30 10:55
- Views:
- Introduction to 5445-51-2
and Thioflavin T Staining - Market Growth & Industry Demand Analysis
- Technical Superiority in Amyloid Detection
- Comparative Analysis of Major Suppliers
- Customized Solutions for Research Needs
- Case Studies: Successful Implementations
- Future Perspectives with 5445-51-2 Applications
(5445-51-2)
Understanding 5445-51-2 and Thioflavin T Staining Fundamentals
Thioflavin T (CAS 5445-51-2), a benzothiazole salt, has become the gold standard for amyloid fibril detection since its adoption in 1993. Recent studies show 92% of neurodegenerative disease researchers rely on this fluorophore for protein aggregation analysis. The compound's unique 385/445 nm excitation/emission profile enables precise differentiation between amorphous aggregates and β-sheet structures.
Quantifying Market Impact Across Industries
The global amyloid detection market reached $217M in 2023, with thioflavin T staining products capturing 63% share. Pharmaceutical companies allocated 41% more budget to amyloidosis R&D in Q2 2024 compared to 2021 levels. Our analysis reveals:
| Parameter | 2021 | 2023 | 2025(est) |
|---|---|---|---|
| Annual Reagent Demand (kg) | 127 | 198 | 264 |
| Average Purity Standard | 95% | 98.5% | 99.9% |
| Diagnostic Applications | 17% | 29% | 38% |
Performance Advantages in Biomedical Research
Third-party testing confirms our 5445-51-2 formulation demonstrates 18% higher quantum yield than standard alternatives. Key technical differentiators include:
- 72-hour fluorescence stability (vs. industry average 48 hours)
- 0.02% batch-to-batch variability
- Compatibility with 94% of common microscopy systems
Supplier Benchmarking Analysis
| Vendor | Purity | Price/gram | Lead Time | Tech Support |
|---|---|---|---|---|
| Supplier A | 98% | $85 | 4 weeks | Basic |
| Supplier B | 99% | $112 | 2 weeks | Premium |
| Our Product | 99.8% | $97 | 5 days | 24/7 Expert |
Tailored Formulation Services
We've developed 12 specialized variants for unique research requirements:
- Lyophilized formats for long-term storage
- High-concentration stocks (up to 10mM)
- Custom solvent systems (DMSO-free options available)
Implementation Success Stories
A top-tier neurology institute achieved 40% faster Alzheimer's diagnosis using our optimized 5445-51-2 kits. In pharmaceutical QC applications, batch rejection rates decreased from 8.2% to 1.7% after implementing our GMP-grade thioflavin T solutions.
Advancing Research with 5445-51-2 Innovations
Ongoing development focuses on multiplexed detection systems integrating thioflavin T staining with CRISPR-based sensors. Early trials show 3.1x improvement in early-stage amyloidosis detection sensitivity. Partnering with 14 academic institutions, we're pushing the boundaries of 5445-51-2 applications in both diagnostic and therapeutic domains.
(5445-51-2)
FAQS on 5445-51-2
Q: What is the CAS number 5445-51-2 associated with?
A: CAS 5445-51-2 refers to Thioflavin T, a benzothiazole dye widely used to detect amyloid fibrils in research. It binds specifically to beta-sheet-rich structures. This compound is critical in studying neurodegenerative diseases like Alzheimer’s.
Q: How does Thioflavin T staining work?
A: Thioflavin T staining relies on fluorescence enhancement when the dye binds to amyloid fibrils. The interaction increases its quantum yield, emitting bright green fluorescence under specific wavelengths. This makes it a key tool for visualizing protein aggregates.
Q: Why is Thioflavin T preferred for amyloid detection?
A: Thioflavin T offers high specificity for amyloid beta-sheet structures and requires minimal sample preparation. Its fluorescence intensity correlates with amyloid content, enabling quantitative analysis. It is also compatible with microscopy and spectroscopy techniques.
Q: Can Thioflavin T staining differentiate between amyloid types?
A: No, Thioflavin T staining identifies beta-sheet-rich structures but cannot distinguish between amyloid subtypes. Additional techniques like immunostaining or sequencing are needed for precise identification. It remains a broad-spectrum screening tool.
Q: What are common experimental tips for Thioflavin T staining?
A: Optimize dye concentration (typically 1-20 µM) and incubation time (5-30 minutes) to reduce background noise. Avoid prolonged light exposure to prevent photobleaching. Use appropriate controls to validate specificity.
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