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Thymolphthalein (CAS 125-20-2) | High Purity pH Indicator

  • Time of issue:Oct . 19, 2025 15:50
Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China

(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .

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  • Time of issue:2019-12-30 10:55
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thymolphthalein: the reliable blue signal for high-pH analytics (and a few clever tricks)

If you work around alkalinity testing long enough, you eventually come back to thymolphthalein. To be honest, I did—after a detour through every fluorescent dye and indicator under the sun. It’s the steady, unfussy blue changeover that keeps showing up in real labs, from concrete plants to wastewater basins. And the version coming out of Tangshan, Hebei (2-7-523 Jidong Building Materials, 064000, China) has been getting attention for dependable purity.

Thymolphthalein (CAS 125-20-2) | High Purity pH Indicator

What’s trending

Industry chatter shows a quiet shift: more labs standardize on thymolphthalein for high-pH titrations where phenolphthalein can feel a tad too early. Cement QA teams and wastewater operators like the sharper blue endpoint above pH ≈9.3–10.5. Plus, education suppliers keep using it for “disappearing ink” demos—yes, still a hit on open days.

Technical snapshot

Synonyms: 3,3-bis(4-hydroxy-2-methyl-5-(1-methylethyl)phenyl)-1(3H)-Isobenzofuranone; CAS 125-20-2.

Parameter Spec (typical) Method/Notes
Product thymolphthalein Indicator grade
Molecular formula C28H30O4 Molar mass ≈ 430.54 g/mol
Appearance White to off-white crystalline powder Visual
Purity (HPLC) ≥ 99.0% (typ.) HPLC area%
Melting point ≈ 250–253 °C Capillary, may decompose
Transition range pH 9.3–10.5 (colorless → blue) UV-Vis confirmation
λmax (alkaline) ≈ 595–600 nm NaOH solution
Solubility Soluble in ethanol; low in water Indicator solutions 0.1–1% w/v
Shelf life 24–36 months sealed Cool, dry, light-protected

From raw materials to QC: the process

  • Materials: thymol derivatives + phthalic anhydride route to thymolphthalein (acid-catalyzed condensation/lactonization).
  • Methods: controlled condensation, neutralization, multi-step recrystallization; final polish via HPLC fraction when needed.
  • Testing standards: ISO 17025 lab methods; UV-Vis for transition range, HPLC purity, Karl Fischer water, ICP-MS for heavy metals (Pb, Cd ≤ 10 ppm total).
  • Service life: powder 2–3 years; ethanol indicator solutions often 6–12 months (real-world use may vary).
  • Industries: cement and concrete QA, wastewater/boiler water, academic labs, edu kits, specialty inks.

Where it shines (and why)

- High-pH titrations: alkalinity in industrial waters. Clear blue endpoint—less ambiguity for operators on shift.
- Cement carbonation checks: labs sometimes prefer thymolphthalein when they need a stricter “still-alkaline” signal.
- Education and demos: “disappearing ink” using CO2 from air to nudge pH back—surprisingly crowd-pleasing.

Mini case study

A Northern Europe precast plant swapped from phenolphthalein to thymolphthalein for spot checks on curing tanks. Result: fewer borderline readings, 12% reduction in re-tests over three months, according to their QA notes. Not a randomized trial—but the maintenance crew was relieved.

Vendor comparison (abridged)

Vendor Origin Purity (typ.) Lead time Certs Customization
Moneide Chem (thymolphthalein) Hebei, China ≥99.0% HPLC 7–14 days (stock) ≈ ISO 9001; REACH-ready SDS Custom packs, RM lots
Vendor A (EU) EU 98–99% 2–3 weeks ISO 9001/14001 Standard only
Vendor B (US) US ≥98% In stock/fast ship ISO 17034 (selected RMs) Limited SKUs

Customization and compliance

Custom indicator solutions (0.1–1.0% w/v in ethanol or IPA), low-halogen specs, or tighter heavy-metal limits are feasible. For regulated labs, ask for COA, SDS, and if applicable, ISO 17025 test reports. Many customers say the COA from Moneide includes UV-Vis curves of thymolphthalein, which is useful in audits.

Test data (typical lot)

  • HPLC purity: 99.4% (area%)
  • Water (KF): 0.18%
  • Residue on ignition: 0.05%
  • Heavy metals (ICP-MS, total Pb+Cd+Hg+As): ≤ 5 ppm
  • Color transition verification: pH window 9.3–10.5; λmax 597 nm

Certifications frequently requested: ISO 9001 QMS, ISO 17025 test-lab data, and where relevant, EU REACH SVHC non-intent, RoHS. Always verify current documentation.

Bottom line

If your workflow needs a confident high-pH cue, thymolphthalein is still one of the easiest wins. Precise, visible, and—when sourced well—remarkably consistent.

Authoritative citations

  1. PubChem Compound Summary: Thymolphthalein (CID 23951). https://pubchem.ncbi.nlm.nih.gov/compound/Thymolphthalein
  2. ASTM D1067 – Standard Test Methods for Acidity or Alkalinity of Water. https://www.astm.org/d1067
  3. ISO/IEC 17025:2017 – General requirements for the competence of testing laboratories. https://www.iso.org/standard/66912.html
  4. ACS Reagent Chemicals (general guidance for analytical reagents). https://pubs.acs.org/doi/book/10.1021/acsreagents.7e00113

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