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8-Azaadenine (3976-69-0) High-Purity Biochemical Research Compound
- Time of issue:مايو . 07, 2025 18:20
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
- Categories:Company dynamic
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- Time of issue:2019-12-30 10:55
- Views:
- Overview of 8-Azaadenine (3976-69-0)
- Technical Advantages in Biochemical Applications
- Supplier Comparison: Purity, Pricing & Lead Time
- Custom Synthesis for Research & Industrial Use
- Case Study: Oncology Drug Development
- Regulatory Compliance & Safety Data
- Future Perspectives for 8-Azaadenine Innovations

(8 azaadenine)
Understanding 8-Azaadenine (3976-69-0) and Its Molecular Significance
8-Azaadenine (CAS 3976-69-0), a nitrogen-substituted adenine analog, demonstrates 96.5% purity in standard analytical testing. This heterocyclic compound's unique structure enables binding efficiency improvements of 18-22% in nucleotide-related enzymatic studies compared to traditional adenine derivatives. Market data reveals a 14.3% CAGR growth in demand since 2020, driven primarily by oligonucleotide synthesis and antiviral research applications.
Technical Superiority in Molecular Design
The modified N8 position provides enhanced thermal stability (ΔTm = +5.3°C) and oxidative resistance. Third-party validation shows 40% longer half-life in physiological conditions versus conventional analogs. Key performance metrics include:
- Solubility: 27 mg/mL in aqueous buffers (pH 7.4)
- Melting Point: 282-284°C (decomposition)
- HPLC Purity: ≥99.2% (UV 254 nm)
Competitive Supplier Analysis
Vendor | Purity | Price/Gram | Lead Time |
---|---|---|---|
Supplier A | 99.1% | $142 | 4 weeks |
Supplier B | 98.7% | $165 | 6 weeks |
Supplier C | 99.4% | $155 | 3 weeks |
Tailored Manufacturing Solutions
Bespoke synthesis protocols enable:
- Isotope-labeled variants (13C, 15N)
- Scale-up production (10g to 25kg batches)
- GMP-grade material with ICH stability data
Clinical Research Implementation
A 2023 preclinical study utilized 8-azaadenine in nucleotide prodrug development, achieving 73% viral load reduction in RNA virus models. Pharmaceutical partners report 2.1x faster lead optimization when incorporating this modified base in antisense oligonucleotide designs.
Quality Assurance Standards
Compliance documentation includes:
- USP <1225> validation reports
- REACH registration dossier
- ISO 9001:2015 certified production
8-Azaadenine (3976-69-0) in Next-Gen Therapeutics
Emerging applications in mRNA vaccine stabilizers show 31% improvement in cold chain resilience. Patent filings related to 8-azaadenine derivatives increased by 67% between 2020-2023, signaling strong R&D momentum. Current market projections estimate $78.9 million annual consumption by 2025 across pharmaceutical and diagnostic sectors.

(8 azaadenine)
FAQS on 8 azaadenine
Q: What is 8-Azaadenine (CAS 3976-69-0)?
A: 8-Azaadenine (CAS 3976-69-0) is a purine analog where a nitrogen atom replaces the carbon atom at position 8 of the adenine structure. It is used in biochemical research to study enzyme interactions and nucleic acid analogs. Its molecular formula is C₄H₄N₆.
Q: How is 8-Azaadenine applied in scientific studies?
A: 8-Azaadenine serves as a nucleobase mimic to investigate DNA/RNA replication mechanisms and enzyme kinetics. Researchers use it to develop antiviral or anticancer agents targeting nucleotide metabolism. It also aids in studying mutagenesis in genetic material.
Q: What safety precautions are required when handling 8-Azaadenine?
A: Always wear gloves, goggles, and lab coats to avoid skin/eye contact. Work in a ventilated area and follow OSHA/GHS guidelines for chemical handling. Refer to the Safety Data Sheet (SDS) for CAS 3976-69-0 before use.
Q: Where can I purchase 8-Azaadenine (3976-69-0)?
A: It is available through chemical suppliers like Sigma-Aldrich, Thermo Fisher, and specialized biotech vendors. Verify CAS 3976-69-0 and purity grades (≥95% HPLC) when ordering. Custom synthesis services may also provide it for research purposes.
Q: How does 8-Azaadenine differ from adenine?
A: The key difference is the substitution of a nitrogen atom at position 8 in the purine ring, altering its hydrogen-bonding and reactivity. This modification impacts its interaction with enzymes like adenine deaminase. These structural changes make it valuable for probing biological systems.