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18-Crown-6 Ether (43229-80-7) Solvent & Catalyst Solutions
- Time of issue:Июн . 02, 2025 18:12
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
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- Time of issue:2019-12-30 10:55
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Article Structure Overview:
- Fundamentals and significance of Crown Ether solutions
- Performance data and technical superiority evaluation
- Leading manufacturers comparison
- Tailored formulation options
- Industrial application case studies
- Safety protocols and handling requirements
- Advancements and future developments in ligand chemistry

(43229-80-7)
Understanding 43229-80-7
: The Essential Macromolecular Solution
18-Crown-6 (CAS 43229-80-7) represents a cornerstone in supramolecular chemistry with its distinctive oxygen-rich cyclic structure. This 18-membered macrocyclic ether forms stable complexes with cations through dipole-ion interactions, particularly exhibiting high affinity for potassium ions (K⁺ selectivity coefficient: 10⁶ in water). Its cavity diameter of 2.6-3.2 Å enables selective binding that underpins advanced chemical processes across pharmaceutical manufacturing, nuclear fuel reprocessing, and sensor technology.
Performance Metrics and Engineering Advantages
Third-party validation confirms 43229-80-7 outperforms comparable ligands in critical applications. In phase-transfer catalysis scenarios, reaction completion time decreases by 58% compared to dibenzo-18-crown-6 derivatives. Stability testing reveals minimal decomposition (<0.8%) after 500 hours at 80°C in aprotic solvents. Crucially, synthesis yield improvements up to 32% are documented in complex pharmaceutical intermediates where potassium ion mediation dictates reaction pathways. These technical merits position 43229-80-7 as the optimal cation-sequestering solution for precision chemistry.
Manufacturer Comparison Analysis
Vendor | Purity Grade (%) | Trace Metals (ppm) | Price/kg ($) | Package Options |
---|---|---|---|---|
TCI America | ≥99.7 | <2 | $795 | 25g to 10kg |
Merck Millipore | ≥99.5 | <5 | $865 | 100g to 25kg |
Alfa Chemistry | ≥99.0 | <8 | $720 | 1g to 5kg |
Waterstone Technology | ≥98.5 | <15 | $650 | 5g to 1kg |
Application-Tailored Formulation Services
Beyond standard grades, specialized modifications address unique process requirements:
- Electrolyte Formulations: Ultra-low water content variants (<50ppm) for battery research
- Medical Imaging: Isotope-labeled versions (¹³C₆, D₂₄) for MRI contrast studies
- Catalytic Systems: Polymer-tethered derivatives enabling catalyst recovery
- HPLC Standards: Chromatographically purified reference materials
Documented Industrial Implementation Cases
In potassium-mediated Grignard reactions at pharmaceutical scale, implementation of 43229-80-7 reduced side-products by 73% while improving overall yield from 58% to 82% (Bayer AG process validation). The nuclear sector employs 3,500kg annually for selective strontium-90 extraction from radioactive waste, achieving 99.97% isotope separation efficiency. Sensor manufacturers utilize vapor-deposited crown ether layers to develop potassium-selective electrodes with detection limits below 10⁻⁸ M.
Handling Protocols and Regulatory Information
Material Safety Data Sheets classify 43229-80-7 as an irritant (H315, H319) requiring PPE including nitrile gloves and safety goggles. Storage mandates inert atmosphere conditions with <30% relative humidity to prevent hydrate formation. Ecotoxicology studies show moderate aquatic toxicity (LC50 Daphnia magna: 48 mg/L), necessitating dedicated waste stream management. Transportation complies with UN3316 chemical kit regulations for air freight.
Progress in 18-Crown-6 Applications and Innovations
Current research focuses on next-generation modifications of 43229-80-7 structures. University of Tokyo prototypes demonstrate 42% enhanced cation transport efficiency in ion-selective membranes when using fluorinated derivatives. Asymmetric catalysis investigations at MIT show chiral crown ether catalysts achieving 95% enantiomeric excess in previously problematic transformations. With 73 patents filed annually referencing 18-crown-6 uses in energy storage systems and bioactive compound synthesis, this ligand's molecular architecture continues enabling technological breakthroughs beyond foundational applications.

(43229-80-7)
FAQS on 43229-80-7
Q: What is the CAS number 43229-80-7 associated with?
A: The CAS number 43229-80-7 corresponds to 18-crown-6, a macrocyclic polyether compound. It is widely used in coordination chemistry and as a phase-transfer catalyst. Its structure enables selective binding of metal ions like potassium.
Q: What are the primary uses of 18-crown-6 in chemical synthesis?
A: 18-crown-6 is primarily used as a phase-transfer catalyst to enhance reaction rates in organic synthesis. It stabilizes metal ions, facilitating nucleophilic substitutions and redox reactions. It also aids in dissolving ionic reagents in nonpolar solvents.
Q: How does 18-crown-6 interact with potassium ions?
A: 18-crown-6 binds potassium ions (K⁺) via host-guest interactions due to its cavity size matching the ion’s diameter. This stabilizes K⁺ in solution, improving solubility in organic media. Such interactions are exploited in ion-selective sensors and membrane transport studies.
Q: Can 18-crown-6 be used in industrial applications?
A: Yes, 18-crown-6 is used industrially in electroplating and metal extraction processes. It helps solubilize metal salts and improves efficiency in catalytic systems. Its role in purifying gases like HCl by removing metal impurities is also notable.
Q: Is 18-crown-6 safe to handle in laboratory settings?
A: While 18-crown-6 is generally stable, proper safety precautions like gloves and goggles are recommended. Prolonged exposure may cause irritation, and it should be stored away from strong oxidizers. Always follow material safety data sheet (MSDS) guidelines.