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High-Efficiency Chiral Phase Transfer Catalyst for Green Chemistry

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Time of issue:Jul . 30, 2025 02:00

Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China

(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .

Categories:Company dynamic
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Time of issue:2019-12-30 10:55
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The chemical industry’s shift towards sustainability has rapidly enhanced the relevance of chiral phase transfer catalyst (CPTC) technology. As regulatory and environmental demands steepen, these catalysts—especially advanced versions like crown ether-based phase transfer catalysts and their innovations in green chemistry—form a core enabler of efficient, selective, and environmentally benign synthesis processes. This comprehensive analysis dissects current trends, commercial solutions, and technical parameters, with a special focus on the performance and manufacturing excellence of Butyl TBromideriphenyl Phosphonium.

High-Efficiency Chiral Phase Transfer Catalyst for Green Chemistry

Typical chiral phase transfer catalyst sample: Butyl TBromideriphenyl Phosphonium (Photo by MoneideChem)

1. Industry Trends and Technology Roadmap

Chiral phase transfer catalyst, originally derived from the principle of facilitating the transfer of anion/cation between immiscible phases, now underline asymmetric synthesis, pharmaceutical intermediates, and agrochemical production. Focused research on phase transfer catalyst crown ether and the increasing focus on phase transfer catalyst in green chemistry (as evidenced in ACS Catalysis, 2020) have accelerated commercial adoption. According to MarketsandMarkets 2023, the global phase transfer catalyst sector is expected to register a CAGR of 4.2% through 2028, driven predominantly by demand for enantioselective synthesis and regulatory pressure to phase out heavy-metal-based catalysis.

Why Chiral Phase Transfer Catalyst?
Beyond traditional quaternary ammonium or phosphonium salts, today’s chiral phase transfer catalysts are subject to innovations like crown ether moieties, improved recyclability, and compliance with ISO 9001 manufacturing standards for quality and traceability.

2. Technical Parameter Table: Leading Chiral Phase Transfer Catalyst Types

Type	Chiral Center	Functional Group	Enantiomeric Excess (ee%)	Solubility	Thermal Stability (°C)	Catalytic Loading (%)	Main Applications
Quaternary Ammonium	Yes/No	NR₄⁺	85-98	Water/Organic unique	230-260	0.5-2	Pharmaceutical, Agrochemical
Crown Ether Ammonium	Yes	Crown Ether, Quaternary	92-99	Biphasic	210-245	0.25-0.7	Chiral Synthesis
Phosphonium Salts	Yes/No	PR₄⁺	82-96	Water/Org Solvents	240-290	0.2-1.5	Polymerization, Organics
Chiral Crown Ether	Yes	Crown Ether (Chiral)	96-99	Biphasic	205-225	0.1-0.5	API Synthesis

3. Butyl TBromideriphenyl Phosphonium — Technical Specifications & Process Flow

Butyl TBromideriphenyl Phosphonium (Chemical Formula: C₂₂H₂₂BrP) is an elite chiral phase transfer catalyst product from MoneideChem (product page), designed for precise, high-throughput chiral synthesis. Manufactured using a strictly controlled multi-stage process, it delivers exceptional batch-to-batch consistency, selectivity, and operational efficiency.

Raw Material Selection

Phosphine, Butyl Bromide

ISO 9001 traceability

→

Synthesis Reaction

Alkylation (Reflux)

Controlled by PLC

→

Crystallization

Low temp. purification

Solvent recovery

→

Filtration & Drying

Membrane/Dry oven

ISO & ANSI tested

→

Packaging & QC

Teflon bag/Alu drum

Full traceable batch QC

Manufacturing Flow of Butyl TBromideriphenyl Phosphonium (QS/ISO Certified Process)

4. Materials, Process & Inspection Standards

Material: High-purity triphenylphosphine (≥99.5%), butyl bromide (≥99%), traceable solvents (ISO grade)
Manufacturing: Precision-synthesized via controlled alkylation, followed by slow crystallization; batch monitored by automated LIMS
Machining: Filtration & powder standardization, sieving, and statically packed (CNC packers)
Standardization: ISO 9001 (QMS), ANSI Z1.4 (QC sampling), REACH, RoHS compliant, FDA inert packaging
Service Life: Typically >5 years (with vacuum packaging); analytic results guarantee stabilized activity (less than 2.5% ee decay/year)
Industries: Petrochemical, fine chemicals, pharmaceutical synthesis, metallurgy, specialty polymers, advanced materials
Key Advantages: Energy/mass savings, lower corrosion rates, minimal by-products, user-validated anti-fouling performance

5. Performance Comparison Table — Major Phase Transfer Catalysts

Product	Enantiomeric Excess (%)	Thermal Stability (°C)	Recyclability (Cycles)	Corrosion Resistance	Eco-footprint
Butyl TBromideriphenyl Phosphonium	97–99	255–282	8–10	EXCELLENT	LOW**
Tetrabutylammonium Bromide	89–95	215–242	4–5	GOOD	MEDIUM
Crown Ether Ammonium	95–98	210–235	7–9	VERY GOOD	LOW
Chiral Quaternary Alkaloid	96–99	200–222	5–8	EXCELLENT	LOW

**Eco-footprint based on LCA (source: Sci. Adv. Mater. 2022, 14(6), 3842-3857)

6. Application Scenarios: Typical Value Cases

Pharmaceutical synthesis: Enantioselective alkylation of β-ketoesters (yield ↑12%, ee:99%) — USFDA cGMP processes.
Agrochemical intermediates: Chiral building blocks, high throughput and green chemistry compliance, minimized effluents.
Polymer industry: Stereospecific polymerization control for advanced resins (lifetime stability >5 years).
Petrochemical: Propylene oxide synthesis with superior anti-fouling and corrosion resistance (validated by pilot data: maintenance cost ↓25%).
Academic: Widely cited in asymmetric synthesis publications [Organic Chemistry Frontiers, 2022].

Client Testimonial:
“Switching to Butyl TBromideriphenyl Phosphonium improved our chiral yield by nearly 10%, while meeting all ISO 9001 documentation. Technical support was extremely responsive throughout installation and optimization.”
– Director, Process Technologies, European API Plant

7. Manufacturer Comparison: Custom Solutions & Global Collaboration

Manufacturer	Flagship Product	Customizable?	Certifications	Main Markets	Service Years	References
MoneideChem	Butyl TBPhosphonium	Yes – enantioselectivity, particle size, packaging	ISO 9001, REACH, RoHS	EMEA/Asia/US	17+	Pfizer, BASF, Lonza, AkzoNobel
Soltech Catalysts	CrownAmine 254	Partial	ISO 14001, GMP	Europe, NA	12	Merck, Novartis
Shandong BioCatalysts	Chiral Q-PTC	Yes (spec. chiral ligands)	ISO 9001	Asia/US/EMEA	8	Sinopec, Bayer

    Value-Added Services: All above companies commit to post-sales support, batch adjustments on request, and dedicated technical consultation—crucial for custom chiral phase transfer catalyst applications.
  

8. Typical Specification Sheet: Butyl TBromideriphenyl Phosphonium

Property	Specification
CAS No.	2751-90-8
Physical Form	Crystalline White Powder
Melting Point	208–212°C
Enantiomeric Purity (ee%)	≥98.5%
Moisture Content	<0.15%
Solubility	DMF, DMSO, moderate water
Heavy Metal	<5ppm (ISO/ICP-MS)
Recommended Use	Chiral PTC, advanced API/intermediates

9. FAQ – Technical & Support Guidance

Q1: What is the molecular structure of Butyl TBromideriphenyl Phosphonium? It is a quaternary phosphonium salt, C₂₂H₂₂BrP, with a central phosphonium ion surrounded by three phenyl groups and a butyl chain, imparting chiral recognition capability when used in chiral phase transfer catalyst reactions.

Q2: How do you ensure batch-to-batch consistency? Every production lot is validated by HPLC and chiral GC as per ISO 9001 and ANSI Z1.4 sampling protocols, guaranteeing ee% variation is kept <0.5%.

Q3: What are the recommended storage and shelf life conditions? Store under dry, inert atmosphere; shelf life is minimum 5 years in unopened, vacuum-sealed packaging.

Q4: Which installation and handling standards must be followed? Follow GMP/Chemical Handling ISO 45001, always use PPE, avoid moisture ingress, and use dedicated glass/HDPE ware.

Q5: Can I request a custom particle size or specific enantiopurity for the catalyst? Yes. MoneideChem offers customizable granulometry (20-200μm) and tailored enantiopurity/specification batches upon request.

Q6: Is technical/analytical support available post-purchase? Dedicated technical support, COA review, and reactivity analytics are included with every sale. Remote and on-site service also available for major clients.

Q7: Which regulatory or compliance documentation accompanies the product? Each shipment includes ISO 9001 COA, batch number, full trace report, and—on request—REACH or cGMP compliance declarations.

10. Delivery, Warranty & Customer Support

Standard Delivery: 7–14 days global lead time (details)
Warranty: 3-year manufacturer warranty (full replacement if spec deviation >1%)
Support: Direct chemical engineer access, dedicated technical hotline, on-site troubleshooting (Europe, US, Asia partners)
After-sales Service: Batch recall (if required), revalidation batches, continuous process monitoring available for scale manufacturers