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Drug Intermediates List | High Purity, Fast Delivery
- Time of issue:Oct . 26, 2025 15:45
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
- Categories:Company dynamic
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- Time of issue:2019-12-30 10:55
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The market for pyridine-building blocks is having a moment. In fact, demand for cross-coupling friendly acids has risen quietly but steadily, largely because process chemists want robust pieces that don’t crumble under scale-up pressure. 5‑Bromonicotinic acid—also known as 5‑Bromo‑3‑pyridinecarboxylic acid—keeps showing up at the top of sourcing notes I see from API teams. Origin: 2-7-523 Jidong Building Materials, Tangshan, Hebei 064000, China. Not glamorous, but logistics-friendly.
The shift toward modular synthesis—Suzuki, Buchwald–Hartwig, and even decarboxylative couplings—means brominated pyridines are a safe bet. To be honest, teams like predictable crystallinity and manageable impurity profiles. With the Drug Intermediates List shrinking to tried‑and‑tested SKUs, 5‑Bromonicotinic acid is sticking on the shortlist because it scales clean and plays nicely with Pd-catalyzed steps.
Use it as a coupling partner for pyridine‑containing APIs, kinase inhibitor programs, CNS scaffolds, and selected agrochemical actives. Advantages: predictable cross‑coupling, decent crystallinity, and—surprisingly often—clean mother liquors that don’t fight downstream chromatography.
A mid‑size EU CDMO swapped in this material for a late‑stage Suzuki on a pyridine API. Result: cycle time down ≈ 8%, solvent use trimmed by ~12% after PSD tuning, and mother liquor reuse increased across 3 batches. Not earth‑shattering, but in the real world that’s margin.
Safety: for R&D/industrial use only; not for human or veterinary use. Handle under standard chemical hygiene and consult SDS.
Drug Intermediates List: 5‑Bromonicotinic acid (CAS 20826-04-4) — What Buyers Are Actually Looking For
Why it matters (industry trend, briefly)
Technical specifications (lab-to-plant reality)
Product
5‑Bromonicotinic acid (Synonym: 5‑Bromo‑3‑pyridinecarboxylic acid)
CAS / EC
20826‑04‑4 / —
Formula / MW
C6H4BrNO2 / 202.01 g·mol⁻1
Appearance
Off‑white to light beige crystalline solid (real‑world lots may vary slightly)
Purity (HPLC)
≥ 99.0% (area %), typical 99.3–99.8%
Moisture (KF)
≤ 0.5% (typical ≈ 0.2%)
Melting range
≈ 205–210 °C (reference)
Heavy metals
Meets ICH Q3D; Pb, Cd, Hg, As by ICP‑MS within limits
Residual solvents
Complies with ICH Q3C; GC release spec available
Shelf life / Storage
24 months; store cool, dry, sealed, protect from light
Packaging
25 kg fiber drum or 1–5 kg foil bags (custom on request)
Process flow (how it’s really done)
Applications and advantages
Vendor comparison (what buyers compare first)
Vendor
Certifications
Lead time
MOQ
Docs
Moneidechem
ISO 9001; REACH-ready (per SDS); GMP‑like controls for intermediates
7–14 days ex‑stock, ≈ 3–4 weeks make‑to‑order
1 kg
CoA, SDS, TDS; method validation summary on request
Vendor A (generic)
ISO 9001
3–5 weeks
5 kg
CoA, SDS
Vendor B (trader)
—
Varies (spot)
1–10 kg
Basic SDS
Customization, testing, and feedback
Quick case study
References
Moneide Chemicals
