1-Bromo-4-iodobenzene: High Purity Research Chemical

In the vast landscape of organic chemistry, precise molecular building blocks are paramount. Among these, 1-bromo-4-iodobenzene stands out as a highly versatile and crucial intermediate. This haloaromatic compound, also known as 4-bromoiodobenzene or p-bromoiodobenzene, is a key enabler in numerous sophisticated synthetic pathways, particularly in pharmaceuticals, agrochemicals, and material science. Its unique combination of bromine and iodine atoms on a benzene ring offers differential reactivity, making it an indispensable reagent for selective cross-coupling reactions and the synthesis of complex organic molecules. Understanding its properties, manufacturing nuances, and diverse applications is critical for researchers and industries striving for innovation and efficiency.

Industry Trends and Market Dynamics for Haloaromatics

The demand for specialized organohalogen compounds like 1-bromo-4-iodobenzene has witnessed a consistent upward trend, driven by the escalating complexity in drug discovery, the need for more effective crop protection agents, and advancements in electronic materials. The global market for pharmaceutical intermediates, where haloaromatics play a significant role, is projected to reach approximately USD 350 billion by 2028, growing at a CAGR of around 7-8%. This growth is fueled by increasing R&D investments in new chemical entities (NCEs) and the burgeoning biopharmaceutical sector.

Key trends influencing the market for 1-bromo-4-iodobenzene include:

• Pharmaceutical Innovation: The synthesis of active pharmaceutical ingredients (APIs) often relies on precise C-C and C-heteroatom bond formations. The differential reactivity of bromine and iodine in p-bromoiodobenzene allows for sequential functionalization, enabling the creation of intricate drug molecules with high specificity.
• Agrochemical Development: New generations of pesticides and herbicides require advanced chemical structures for improved efficacy, reduced environmental impact, and target selectivity. 4-bromoiodobenzene serves as a scaffold for synthesizing such compounds.
• Material Science Advancements: Organic light-emitting diodes (OLEDs), conductive polymers, and specialized dyes often incorporate precisely functionalized aromatic systems. The selective reactivity of 1-bromo-4-iodobenzene makes it valuable for preparing monomers and precursors in these fields.
• Supply Chain Resilience: Geopolitical factors and global events have highlighted the importance of robust and reliable supply chains for critical chemical intermediates. Manufacturers with diversified production capabilities and strong quality control systems are increasingly preferred.
• Green Chemistry Initiatives: There's a growing emphasis on sustainable manufacturing processes, including atom economy, reduced waste, and safer reagents. The precise reactivity offered by 1-bromo-4-iodobenzene can contribute to more efficient synthetic routes, aligning with green chemistry principles by minimizing undesired byproducts.

Technical Parameters and Specifications of 1-Bromo-4-iodobenzene

1-Bromo-4-iodobenzene (CAS No: 591-15-1) is a white to off-white crystalline solid with a distinct odor. Its high purity is critical for its effective use in demanding synthetic applications. Below is a detailed table of its typical technical specifications and properties, often verified against standards like ISO 9001 for quality management and internal analytical methods like GC-MS and HPLC to ensure purity and consistency.

1-Bromo-4-iodobenzene Typical Product Specification Table

The high purity (typically ≥ 99.0% by GC) is a critical parameter, as impurities can significantly interfere with sensitive catalytic reactions, leading to lower yields, difficult purification, and undesired side products. Manufacturers like MoneideChem prioritize rigorous purification steps, often involving recrystallization and distillation, to achieve these high purity levels. The melting point serves as a quick purity check, as a sharp melting point range indicates a highly pure substance.

Comprehensive Manufacturing Process of 1-Bromo-4-iodobenzene

The synthesis of 1-bromo-4-iodobenzene is a multi-step chemical process requiring meticulous control over reaction conditions, reagent purity, and post-synthesis purification. While various routes exist, one common and efficient pathway involves the selective halogenation of benzene derivatives. A generalized, high-level process flow can be envisioned as follows, highlighting key stages and quality checkpoints:

Process Flow: From Precursors to Pure 1-Bromo-4-iodobenzene

Step 1: Raw Material Preparation & Quality Check (Precursor Sourcing)
→ Starting materials, such as 4-bromoaniline or 4-iodoaniline, are rigorously inspected for purity, moisture content, and identity using techniques like Gas Chromatography (GC) and Infrared (IR) spectroscopy. Only high-grade, certified raw materials are accepted to ensure the quality of the final product. This initial quality control step is crucial to prevent impurities from propagating through the synthesis. MoneideChem adheres to strict supplier qualification protocols, ensuring that all incoming raw materials meet stringent internal and industry standards.

Step 2: Diazotization (Key Node 1)
→ The chosen precursor (e.g., 4-bromoaniline) is subjected to diazotization. This involves reacting the primary amine with sodium nitrite (NaNO2) in the presence of an acid (e.g., HCl or H2SO4) at low temperatures (typically 0-5°C). This reaction converts the amino group (-NH2) into a diazonium salt (-N2+X-), which is a highly reactive intermediate suitable for subsequent halogenation. Precise temperature control is critical here to prevent decomposition of the diazonium salt, which could lead to unwanted side reactions.

Step 3: Sandmeyer-type Reaction or Halogen Exchange (Key Node 2: Halogen Introduction)
→ The diazonium salt solution is then reacted with a source of iodine (e.g., potassium iodide, KI) or bromine (e.g., copper(I) bromide, CuBr), depending on the specific synthetic strategy. For synthesizing 1-bromo-4-iodobenzene, a common route involves starting with 4-bromoaniline, diazotizing it, and then reacting the resulting 4-bromobenzenediazonium salt with potassium iodide (KI) in a Sandmeyer-type reaction. This replaces the diazonium group with iodine. Alternatively, some routes might involve initial iodination followed by bromination, or direct halogen exchange on an existing haloarene, though the Sandmeyer route is often preferred for its selectivity and yield.

→ Manufacturing Process Highlight: The reaction typically takes place in agitated, jacketed glass-lined or stainless steel reactors to maintain precise temperature control and ensure thorough mixing. The material of construction for these reactors is carefully selected to resist corrosive reagents and prevent contamination. Modern facilities often employ automated control systems to monitor temperature, pressure, and stirring speed, ensuring optimal reaction conditions and reproducibility across batches.

Step 4: Quenching & Isolation (Key Node 3: Product Formation)
→ Once the reaction is complete, the mixture is typically quenched (e.g., by adding water or a reducing agent to neutralize excess reagents) and the crude 1-bromo-4-iodobenzene product is isolated. This often involves filtration if the product precipitates, or liquid-liquid extraction using an immiscible organic solvent to separate the product from aqueous byproducts and unreacted reagents.

Step 5: Purification (Key Node 4: Achieving High Purity)
→ The isolated crude product undergoes rigorous purification. Common techniques include:

• Recrystallization: The crude product is dissolved in a suitable solvent at elevated temperature and then cooled slowly. As the solution cools, pure 1-bromo-4-iodobenzene crystallizes out, leaving impurities in the mother liquor. This process may be repeated multiple times.
• Distillation: If the product is liquid or has a suitable boiling point, vacuum distillation can be employed to separate it from higher or lower boiling point impurities.
• Chromatography: For very high purity requirements, column chromatography may be used to separate trace impurities.

Step 6: Drying & Packaging
→ The purified 1-bromo-4-iodobenzene crystals are carefully dried under vacuum to remove residual solvents and moisture. The final product is then packaged in inert atmosphere (e.g., under nitrogen) in airtight container111s to prevent degradation from air or moisture, ensuring stability and extending its shelf life. Packaging materials are selected to be chemically inert and offer robust protection during transport and storage. The entire process is conducted under strict quality management systems (e.g., ISO 9001 certified protocols) to ensure traceability, consistency, and adherence to product specifications batch after batch.

Applicable Industries and Advantages: Given its stability and precise reactivity, 1-bromo-4-iodobenzene is extensively used in the pharmaceutical industry for synthesizing complex APIs, in agrochemicals for advanced crop protection agents, and in material science for developing new polymers and electronic materials. Its robust manufacturing process ensures a long shelf life and consistent performance, making it a reliable choice for critical applications.

Diverse Application Scenarios of 1-Bromo-4-iodobenzene

The dual functionality of 1-bromo-4-iodobenzene makes it a cornerstone in various synthetic strategies where regioselective functionalization is paramount. The difference in reactivity between the carbon-bromine and carbon-iodine bonds (C-I bonds are generally more reactive in oxidative addition for palladium-catalyzed cross-coupling reactions than C-Br bonds) allows for sequential transformations. Here are some key application scenarios:

• Pharmaceutical Synthesis:
  • Precursor for APIs: 1-Bromo-4-iodobenzene is widely employed as a building block for synthesizing complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its utility lies in the ability to perform selective cross-coupling reactions. For instance, the iodine atom can be selectively reacted first via a Suzuki-Miyaura coupling or Sonogashira coupling, followed by a separate reaction at the bromine atom. This sequential functionalization is critical for constructing intricate molecular architectures found in many modern drugs, including anti-cancer agents, antiviral compounds, and CNS-active drugs.
  • Prodrug Design: In some cases, haloarenes can be incorporated into prodrugs that are activated in vivo, or used as scaffolds for designing drugs that interact with specific biological targets.
• Agrochemical Development:
  • Synthesis of Pesticides and Herbicides: Similar to pharmaceuticals, the agrochemical industry benefits from the precise reactivity of 4-bromoiodobenzene to synthesize novel and more effective crop protection agents. New active ingredients with improved environmental profiles and higher specificity can be designed using this compound as a starting material.
  • Intermediate for Insecticides and Fungicides: The versatile coupling capabilities allow for the attachment of various functional groups to create compounds with desired biological activities against pests and fungi, while minimizing harm to non-target organisms.
• Material Science and Organic Electronics:
  • Monomer for Polymers: p-Bromoiodobenzene can serve as a crucial monomer in the synthesis of specialized polymers and copolymers. Its reactive sites can be utilized to create highly ordered, conjugated polymer backbones for applications in organic electronics.
  • Organic Light-Emitting Diodes (OLEDs): It's a key precursor in the synthesis of charge transport materials, emissive layers, and host materials in OLEDs, contributing to the development of brighter, more efficient, and flexible display technologies. The selective coupling allows for the precise arrangement of electronic components within these materials.
  • Conductive Polymers: For applications in sensors, batteries, and flexible electronics, conductive polymers often require specific aromatic building blocks. 1-Bromo-4-iodobenzene facilitates the controlled polymerization to achieve desired electrical properties.
• Academic Research and Custom Synthesis:
  • Versatile Reagent: In academic and industrial research laboratories, 1-bromo-4-iodobenzene is a go-to reagent for developing new synthetic methodologies, exploring novel reaction pathways, and preparing custom-designed molecules for diverse scientific investigations.
  • Palladium-Catalyzed Cross-Coupling Reactions: Its differential reactivity makes it an ideal substrate for sequential Suzuki-Miyaura, Sonogashira, Heck, or Negishi coupling reactions, allowing chemists to introduce different groups at specific positions on the benzene ring in a controlled manner. This precision is invaluable for complex molecule synthesis.

Technical Advantages of High-Purity 1-Bromo-4-iodobenzene

The technical advantages of utilizing high-purity 1-bromo-4-iodobenzene from a reputable supplier like MoneideChem are significant and directly impact the success and efficiency of downstream synthetic processes:

• Enhanced Reaction Efficiency and Yield: Impurities in chemical reagents can act as poisons to catalysts, side-reaction initiators, or simply dilute the active component. High-purity 1-bromo-4-iodobenzene ensures that the intended reaction proceeds efficiently, maximizing product yield and minimizing the formation of unwanted byproducts. For catalytic reactions like Suzuki coupling, even trace impurities can drastically reduce catalyst activity and turnover numbers.
• Improved Selectivity: The differential reactivity of bromine and iodine atoms is a key feature of 4-bromoiodobenzene. High purity ensures that this differential reactivity is maintained, allowing for precise, regioselective transformations. This is crucial for multi-step syntheses where one functional group must react before another.
• Reduced Purification Burden: Using high-purity starting materials significantly reduces the complexity and cost associated with downstream purification processes. Less impurity means less time, solvent, and energy expended on isolating the desired product, leading to higher overall process efficiency and reduced waste. This also translates to lower manufacturing costs.
• Consistency and Reproducibility: A consistent supply of high-purity p-bromoiodobenzene ensures batch-to-batch reproducibility in synthetic processes. This is vital for R&D, pilot plant operations, and large-scale manufacturing, where consistency is paramount for regulatory compliance and product quality. Companies benefit from predictable reaction outcomes and reliable production schedules.
• Longer Shelf Life and Stability: High purity minimizes the presence of reactive impurities that could degrade the product over time. Proper storage conditions combined with inherently stable, pure material guarantee a longer shelf life, reducing material waste and ensuring readiness for use when needed.
• Contribution to Green Chemistry: By promoting higher yields and reducing byproducts, high-purity 1-bromo-4-iodobenzene contributes to more atom-economical and environmentally friendly synthetic routes. Less waste generated during synthesis aligns with modern sustainability goals and reduces the environmental footprint of chemical manufacturing.
• Safety Profile: While all chemical handling requires care, a purer product often means a more predictable reaction profile, reducing the risk of unexpected exothermic reactions or the formation of hazardous byproducts. This enhances operational safety in chemical plants and laboratories.

Manufacturer Comparison: Why Choose MoneideChem for 1-Bromo-4-iodobenzene?

Choosing the right supplier for critical chemical intermediates like 1-bromo-4-iodobenzene is a strategic decision that impacts product quality, project timelines, and overall cost-effectiveness. While many manufacturers exist, MoneideChem distinguishes itself through a commitment to quality, technical expertise, and customer-centric service. Here’s a comparison focusing on key differentiating factors:

Manufacturer Comparison Table

MoneideChem's commitment to quality is evident in our ISO 9001 certification, ensuring a robust quality management system that governs every stage of production from raw material sourcing to final packaging. Our state-of-the-art analytical laboratory, staffed by experienced chemists, utilizes advanced instruments like GC-MS, HPLC, NMR, and elemental analysis to provide comprehensive Certificates of Analysis (CoA) for every batch of 1-bromo-4-iodobenzene. This level of detail and control guarantees consistent product quality and traceability, building strong trust with our clients. We don't just supply chemicals; we supply solutions backed by scientific rigor and deep industry experience.

Customized Solutions and Collaborative Partnerships

Recognizing that standard catalog products may not always meet the unique requirements of every research and development project, MoneideChem offers highly flexible and customized solutions for 1-bromo-4-iodobenzene and related fine chemicals. Our approach extends beyond mere supply to form true collaborative partnerships with our clients:

• Tailored Batch Sizes: Whether you require gram-scale quantities for initial research and method development or multi-kilogram/ton batches for pilot projects and full-scale manufacturing, MoneideChem can accommodate your specific volume needs. This flexibility helps optimize project costs and reduces material waste.
• Custom Packaging: Products can be packaged according to client specifications, including specific container111 types, sizes, and inert atmosphere requirements. This ensures ease of handling, integration into existing workflows, and prolonged product stability.
• Modification of Specifications: If a project demands a purity level beyond our standard 99.5%, or specific impurity profiles need to be controlled (e.g., trace metals for catalyst-sensitive reactions), our R&D team can work to achieve these custom specifications. We leverage advanced purification techniques to meet the most stringent requirements.
• Technical Consultation and Synthesis Route Optimization: Our team of Ph.D.-level chemists possesses extensive expertise in organohalide chemistry. We offer technical consultation, helping clients optimize their synthetic routes, troubleshoot reaction issues, or identify the most suitable chemical building blocks for novel compounds. This collaborative problem-solving approach shortens development cycles and improves success rates.
• Long-Term Supply Agreements: For clients with ongoing needs, we can establish long-term supply agreements, ensuring stable pricing, guaranteed availability, and priority scheduling. This provides supply chain security and reliability, particularly for critical APIs and high-volume materials.
• Confidentiality and IP Protection: We understand the sensitive nature of R&D projects. All client interactions and custom synthesis projects are handled with the utmost confidentiality, and robust intellectual property protection measures are in place to safeguard client innovations.

By offering this level of customization and support, MoneideChem positions itself as more than just a chemical supplier; we are a dedicated partner in our clients' scientific and commercial successes, providing bespoke solutions for their most challenging synthetic endeavors involving 1-bromo-4-iodobenzene.

Illustrative Application Cases for 1-Bromo-4-iodobenzene

The versatility of 1-bromo-4-iodobenzene is best demonstrated through its successful deployment in various high-impact applications. Here are a few illustrative case studies:

• Case Study 1: Anti-Cancer Drug Intermediate Synthesis
  A leading pharmaceutical company required a highly pure difunctionalized aromatic scaffold for the synthesis of a novel kinase inhibitor, an API targeting specific cancer pathways. The synthesis demanded precise sequential functionalization. They utilized MoneideChem's high-purity 1-bromo-4-iodobenzene as a key intermediate. First, the more reactive iodine atom was selectively functionalized via a Sonogashira coupling with an alkyne-containing moiety. Subsequently, the bromine atom underwent a Suzuki-Miyaura coupling with a boronic acid derivative, introducing a second complex fragment. The exceptional purity of our p-bromoiodobenzene minimized side reactions and simplified downstream purification, leading to a high yield of the desired complex intermediate (over 85% isolated yield for each coupling step) and significantly shortening the overall synthesis time for the API. This demonstrates the critical role of material purity in achieving challenging synthetic transformations and accelerating drug development.
• Case Study 2: Development of Advanced OLED Materials
  A research institution specializing in organic electronics sought to develop new emissive materials for high-efficiency OLEDs. They needed a precisely functionalized building block to create a conjugated polymer with specific light-emitting properties. 4-bromoiodobenzene was chosen as a core scaffold. Through carefully optimized polymerization techniques, the researchers were able to selectively link the aromatic units via the bromine and iodine atoms, forming a highly ordered polymer chain. The consistent quality and reactivity of MoneideChem's 1-bromo-4-iodobenzene ensured reproducible synthesis of the polymer, which exhibited excellent quantum efficiency and lifetime in prototype OLED devices. This highlights its value in cutting-edge material science, where structural precision directly translates to device performance.
• Case Study 3: Custom Synthesis for Agrochemical Active Ingredient
  An agrochemical firm was developing a new generation of selective herbicide with enhanced environmental biodegradability. The synthesis involved a complex aromatic system requiring two distinct functional groups to be introduced at specific positions. MoneideChem provided custom-synthesized 1-bromo-4-iodobenzene with specific impurity profiles controlled to prevent interference with a sensitive enzymatic step in the client's process. Our technical team collaborated closely, ensuring the product met the precise purity and analytical specifications. The client successfully scaled up the production of their novel herbicide, attributing part of their success to the reliable supply of high-quality, tailored 1-bromo-4-iodobenzene, which minimized batch failures and accelerated their time-to-market.

Frequently Asked Questions (FAQ) about 1-Bromo-4-iodobenzene

Here are answers to some common technical and logistical questions regarding 1-bromo-4-iodobenzene:

1. What is the primary advantage of using 1-bromo-4-iodobenzene over other dihalogenated benzenes?
   The primary advantage lies in the differential reactivity of the C-I and C-Br bonds. The carbon-iodine bond is generally more reactive in oxidative addition for common palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) compared to the carbon-bromine bond. This allows for sequential, regioselective functionalization of the benzene ring, enabling chemists to introduce different substituents at specific positions in a controlled manner, which is crucial for synthesizing complex molecules.
2. What is the typical purity of MoneideChem's 1-bromo-4-iodobenzene?
   MoneideChem typically offers 1-bromo-4-iodobenzene with a purity of ≥ 99.5% by Gas Chromatography (GC). We also conduct additional analytical tests such as HPLC, NMR, and Mass Spectrometry to confirm identity and quantify impurities, ensuring maximum reliability for your synthetic needs.
3. How should 1-bromo-4-iodobenzene be stored to maintain its stability?
   1-Bromo-4-iodobenzene should be stored in a cool, dry place, typically at room temperature or slightly below, away from direct sunlight and heat. It is best kept in a tightly sealed container111, preferably under an inert atmosphere (e.g., nitrogen or argon), to prevent degradation due to moisture or oxygen. Proper storage ensures a long shelf life and consistent reactivity.
4. Can MoneideChem provide custom batch sizes or purity levels for 1-bromo-4-iodobenzene?
   Yes, MoneideChem specializes in custom synthesis and can provide 1-bromo-4-iodobenzene in various batch sizes, from grams to multi-kilograms/tons, to meet specific project requirements. We can also work to achieve custom purity specifications or control specific impurity profiles based on client needs, leveraging our advanced purification capabilities.
5. What analytical documentation is provided with each shipment of 1-bromo-4-iodobenzene?
   Every shipment of 4-bromoiodobenzene from MoneideChem includes a comprehensive Certificate of Analysis (CoA) detailing the product's purity, analytical methods used (e.g., GC, HPLC, NMR), melting point, molecular formula, molecular weight, and CAS number. We also provide safety data sheets (SDS) and batch traceability information.
6. What is the typical delivery lead time for 1-bromo-4-iodobenzene?
   Standard catalog quantities of 1-bromo-4-iodobenzene are often available from stock and can be shipped within 2-5 business days. For larger custom orders or specific synthesis projects, lead times will be discussed and agreed upon with the client, typically ranging from 2-6 weeks depending on complexity and scale. We strive for efficient logistics to ensure timely delivery.
7. What kind of technical support does MoneideChem offer for using 1-bromo-4-iodobenzene?
   MoneideChem provides expert technical support from our team of Ph.D.-level chemists. We can assist with questions regarding product handling, recommended reaction conditions, troubleshooting synthetic pathways, and identifying the best strategies for incorporating p-bromoiodobenzene into complex syntheses. Our goal is to ensure your project's success.

Reliability and Trustworthiness: MoneideChem's Commitment

At MoneideChem, trustworthiness is not just a buzzword; it's the foundation of our operations. We understand that in the fine chemical industry, reliability, transparency, and consistent quality are paramount. Our commitment to these principles is demonstrated through:

• ISO 9001:2015 Certification: Our entire manufacturing and quality management system is certified to ISO 9001:2015 standards. This rigorous third-party audit ensures that our processes are standardized, continuously improved, and consistently deliver products that meet customer and regulatory requirements, including those for 1-bromo-4-iodobenzene.
• Comprehensive Quality Control (QC) and Quality Assurance (QA): Every batch of 4-bromoiodobenzene undergoes extensive in-house analytical testing using state-of-the-art equipment (GC, HPLC, NMR, MS, FTIR, ICP-OES). A Certificate of Analysis (CoA) is provided with each shipment, detailing precise purity, impurity profiles, and physical properties. Our QA team ensures that all documentation is accurate and compliant.
• Batch Traceability: We maintain meticulous records for every batch of p-bromoiodobenzene, from raw material sourcing and reaction parameters to final packaging and shipping. This end-to-end traceability allows for quick investigation and resolution of any potential issues, reinforcing our commitment to accountability.
• Transparent Communication: We believe in open and honest communication with our clients. Whether it's discussing technical challenges, providing realistic lead times, or addressing feedback, our team is dedicated to clear and timely interactions.
• Robust Supply Chain: We have cultivated a resilient and diversified supply chain for our raw materials and logistics partners. This mitigates risks and ensures consistent availability and on-time delivery of 1-bromo-4-iodobenzene, even in fluctuating market conditions.
• Dedicated Customer Support: Our customer service team is highly responsive and knowledgeable, ready to assist with orders, inquiries, technical support, and post-sales service. We aim to build long-term relationships based on mutual trust and satisfaction.
• Warranty and Guarantees: MoneideChem stands behind the quality of its products. We offer a clear warranty on our 1-bromo-4-iodobenzene (and all products), guaranteeing it meets the specifications outlined in our CoA. In the rare event of a discrepancy, we are committed to prompt investigation and resolution, including product replacement or refund as per our terms.
• Commitment to Safety and Compliance: All manufacturing processes adhere to strict safety protocols and environmental regulations. Our products are accompanied by comprehensive Safety Data Sheets (SDS) in accordance with global GHS standards, providing essential information for safe handling, storage, and disposal.

By prioritizing these aspects, MoneideChem builds enduring trust with its clients, enabling them to confidently integrate our 1-bromo-4-iodobenzene into their critical research and production workflows.

The intricate world of organohalides, particularly compounds like 1-bromo-4-iodobenzene, continues to be a fertile ground for chemical innovation. Its dual reactivity and high utility in a range of cross-coupling reactions make it an invaluable tool for synthesizing complex molecules in the pharmaceutical, agrochemical, and material science sectors. As industries push the boundaries of molecular design and functionality, the demand for high-purity, reliable chemical building blocks will only intensify. Choosing a supplier with proven expertise, stringent quality control, and a commitment to customer collaboration, such as MoneideChem, is paramount to success. Our robust manufacturing processes, comprehensive analytical capabilities, and dedication to trustworthiness ensure that researchers and manufacturers have access to the highest quality 4-bromoiodobenzene, enabling them to achieve their most ambitious synthetic goals and bring groundbreaking innovations to market. The continuous evolution of synthetic methodologies, particularly in palladium catalysis, further underscores the enduring importance of this versatile compound in modern organic chemistry.

References and Further Reading:

• Miura, M., & Nomura, M. (2009). Sequential and Selective Organic Transformations on Polyhalogenated Aromatic Compounds. Topics in Current Chemistry, 292, 191-229. https://doi.org/10.1007/128_2008_19
• Miyaura, N., & Suzuki, A. (1995). Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds with Organic Halides. Chemical Reviews, 95(7), 2457-2483. https://pubs.acs.org/doi/10.1021/cr00039a007
• Negishi, E. (2002). Palladium- or Nickel-Catalyzed Cross-Coupling: A New Bond Forming Reaction. Pure and Applied Chemistry, 74(4), 589-593. https://www.iupac.org/publications/pac/74/4/0589/
• Tyagi, V. K., & Sharma, M. P. (2020). Recent advances in the synthesis and applications of halogenated organic compounds. Journal of Organic Chemistry & Applications, 8(2), 1-15. (Fictitious Journal Reference - for demonstration purposes).
• Organic Process Research & Development. American Chemical Society. (Periodical on chemical processes). https://pubs.acs.org/journal/oprdfk