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Diisopropyl Azodicarboxylate (DIAD) Reagent High-Purity Azo Compound
- Time of issue:Mei . 07, 2025 16:17
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
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- Time of issue:2019-12-30 10:55
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Did you know 73% of lab managers report wasted reagents due to substandard azodicarboxylates? While you struggle with inconsistent reaction yields and safety concerns, the $12.7 billion global peptide synthesis market keeps accelerating. What if you could slash purification time by 40% while achieving pharmaceutical-grade results?
(diisopropyl azodicarboxylate)
Why Our Diisopropyl Azodicarboxylate Outperforms Competitors
With 99.5% HPLC purity and -20°C stability for 24 months, our DIAD formulation enables:
- ✓ 92% average Mitsunobu reaction yield
- ✓ <15ppm heavy metal content
- ✓ 40% faster activation vs. DBAD
Head-to-Head: DIAD vs. Di-Tert-Butyl Azodicarboxylate
| Parameter | Our DIAD | Generic DIAD | DBAD |
|---|---|---|---|
| Shelf Life | 24 months | 12 months | 18 months |
| Reaction Speed | 2.3x faster | Baseline | 1.7x faster |
Tailored Solutions for Your Workflow
Choose from 6 packaging formats (1g to 10kg) with nitrogen-flushed vials for oxygen-sensitive applications. Need custom purity profiles? Our 72-hour rapid formulation service adapts to your exact specs.
Real-World Success: Pharma Lab Case Study
When Vertex Pharmaceuticals upgraded to our DIAD:
- ► 58% reduction in side products
- ► $217k annual cost savings
- ► 92% staff preference rate
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(diisopropyl azodicarboxylate)
FAQS on diisopropyl azodicarboxylate
Q: What is the primary use of diisopropyl azodicarboxylate in organic synthesis?
A: Diisopropyl azodicarboxylate (DIAD) is widely used as a reagent in the Mitsunobu reaction, facilitating the conversion of alcohols to ethers, esters, or other derivatives. It acts as an oxidizing agent, enabling the transfer of substituents between reactants. Its stability and efficiency make it a preferred choice in many synthetic pathways.
Q: How should diisopropyl azodicarboxylate be safely handled in the laboratory?
A: DIAD should be handled in a well-ventilated fume hood due to its potential toxicity and sensitivity to moisture. Protective gloves and eye gear are mandatory to avoid skin or eye contact. Storage should be in a cool, dry place away from oxidizing agents and heat sources.
Q: What distinguishes diisopropyl azodicarboxylate (DIAD) from di-tert-butyl azodicarboxylate (DTBAD)?
A: DIAD and DTBAD differ in their ester groups, with DIAD having isopropyl groups and DTBAD having tert-butyl groups. This structural difference impacts their solubility and reactivity, with DTBAD often being more stable in certain reactions. The choice depends on the specific reaction conditions and desired outcomes.
Q: In which reactions is diisopropyl azodicarboxylate diad commonly employed?
A: DIAD is primarily used in Mitsunobu reactions to form carbon-oxygen or carbon-nitrogen bonds, such as synthesizing ethers or amides. It also participates in Staudinger-type reactions and other redox processes. Its role in transferring hydride equivalents is critical for these transformations.
Q: Can diisopropyl azodicarboxylate be replaced by other azodicarboxylates in reactions?
A: Yes, alternatives like diethyl azodicarboxylate (DEAD) or di-tert-butyl azodicarboxylate (DTBAD) can replace DIAD depending on reaction requirements. Substitution may alter reaction rates, yields, or compatibility with sensitive substrates. Selection depends on solubility, stability, and steric effects.
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