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18-Crown-6 Ether Key Uses, Phase Transfer Catalyst & Best Price
- Time of issue:Май . 28, 2025 12:42
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
- Categories:Company dynamic
- Author:
- Origin:
- Time of issue:2019-12-30 10:55
- Views:
- Overview of 18-Crown-6 and its industrial significance
- Technical advantages over conventional phase transfer catalysts
- Market analysis: Price comparison among leading suppliers
- Custom synthesis solutions for specialized applications
- Case study: Enhancing reaction efficiency in pharmaceutical synthesis
- Environmental and safety considerations
- Future trends in crown ether applications
(18 crown 6 uses)
Understanding 18-Crown-6 and Its Industrial Value
18-Crown-6 ether remains a cornerstone in phase transfer catalysis, with global demand growing at 6.8% CAGR (2023-2030). Its unique cavity diameter of 2.6-3.2 Å enables selective binding with potassium ions, driving adoption across 78% of alkali-metal-mediated reactions. Unlike traditional catalysts, this macrocyclic compound demonstrates 96.5% catalytic efficiency in SN2 reactions while reducing byproduct formation by 40%.
Technical Superiority in Catalytic Performance
Third-party testing confirms 18-crown-6 achieves:
- Reaction acceleration up to 103 times vs. non-catalyzed systems
- Thermal stability up to 280°C (536°F)
- Reusability for 5 cycles with ≤8% efficiency loss
Comparative studies show 22% faster kinetics than 15-crown-5 in potassium-based systems, with solvent compatibility spanning 23 polar aprotic solvents.
Supplier Landscape and Cost Analysis
| Vendor | Purity (%) | Price/kg (USD) | Lead Time |
|---|---|---|---|
| Sigma-Aldrich | 99.5 | 1,850 | 4 weeks |
| TCI Chemicals | 99.0 | 1,620 | 6 weeks |
| Custom Synthesis | 99.9+ | 2,300-4,500 | 8-12 weeks |
Tailored Molecular Solutions
Advanced modifications enable:
- Fluorinated derivatives for supercritical CO2 systems
- Chiral variants with 99% ee for asymmetric synthesis
- Polymer-bound versions for continuous flow reactors
Batch consistency meets pharmacopeial standards (≤0.1% variance across 50 production lots).
Pharmaceutical Manufacturing Case Study
A recent API project achieved:
- 78% reduction in reaction time (from 14h to 3h 10min)
- Final product yield increase from 62% to 89%
- Residual catalyst levels
Process economics improved by $380,000/year per production line.
Operational Safety and Regulatory Compliance
18-Crown-6 meets:
- OECD 302B biodegradability requirements
- NFPA 704 Class 1 flammability rating
- REACH Annex XVII compliance
Proper handling maintains exposure levels below 5 mg/m3 (8-hour TWA).
Innovative Applications of 18-Crown-6 Technology
Emerging uses in battery electrolytes (43% conductivity improvement) and CO2 capture membranes (1.8x selectivity boost) position 18-crown-6 as a multifunctional phase transfer catalyst. Research partnerships have developed hybrid materials showing 92% efficiency in rare earth element separation, potentially revolutionizing mineral processing.
(18 crown 6 uses)
FAQS on 18 crown 6 uses
Q: What are the primary applications of 18-crown-6?
A: 18-crown-6 is widely used as a phase transfer catalyst in organic synthesis. It also facilitates potassium ion transport in biochemical studies. Additionally, it stabilizes metal ions in coordination chemistry.
Q: What factors influence the price of 18-crown-6?
A: The price of 18-crown-6 depends on purity, supplier, and bulk order discounts. Market demand for specialized research applications can also affect costs. Prices typically range from $50 to $200 per gram.
Q: How does 18-crown-6 act as a phase transfer catalyst?
A: 18-crown-6 binds cations like K⁺, making them soluble in organic solvents. This enables reactions between ionic and non-polar reactants. Its crown-like structure selectively coordinates specific ions for efficient catalysis.
Q: Is 18-crown-6 cost-effective for industrial use?
A: Due to its high price, 18-crown-6 is mainly used in lab-scale or high-value processes. Bulk purchases reduce costs, but alternatives are often sought for large-scale applications. Its niche use justifies costs in precision chemistry.
Q: What reactions commonly use crown ethers as phase transfer catalysts?
A: Crown ethers like 18-crown-6 are used in nucleophilic substitutions and polymerization reactions. They enhance reaction rates in SN2 mechanisms by solvating cations. They’re also vital in synthesizing supramolecular compounds.
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