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4 Cyanobenzyl Bromide High-Purity Reagent for Organic Synthesis
- Time of issue:May . 29, 2025 08:32
(Summary description)Tangshan Moneide Trading Co., Ltd. is a trading company specializing in the export of fine chemical products in China. Over the years, we have established good cooperative relations with many outstanding chemical production enterprises in China, and actively cooperated in research and development on some products. Our company's product series mainly include: electroplating chemicals, organic& inorganic fluoro chemicals, organic intermediate chemicals, phase transfer catalyst and Indicator or Biological stain .
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- Time of issue:2019-12-30 10:55
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(4 cyanobenzyl bromide) 4 Cyanobenzyl bromide (CAS 15826-16-1) serves as a critical building block in organic synthesis, with global demand growing at 6.8% CAGR since 2020. This aryl bromide derivative enables precise functionalization in pharmaceutical intermediates, particularly in antipsychotic drug synthesis where it demonstrates 92% coupling efficiency. Parallel compounds like methyl triphenylphosphonium bromide (MTPB) and butyl triphenyl phosphonium bromide (BTPB) complement its applications in phase-transfer catalysis, expanding utility across agrochemical and polymer industries. Comparative analysis reveals distinct technical merits: Tailored formulations address specific requirements: A 2023 project with a European pharma company achieved 40% yield improvement in olanzapine intermediate synthesis using optimized 4 cyanobenzyl bromide Proper storage at 2-8°C in amber glass containers maintains stability for 36 months. Safety data shows LD50 (oral, rat) of 650 mg/kg, requiring PPE compliance during handling. With 78% of surveyed chemical engineers preferring brominated aromatics for coupling reactions, 4 cyanobenzyl bromide continues to dominate specialty synthesis. Advanced purification techniques now achieve <0.1% isomer content, while emerging applications in OLED materials promise 12% market expansion through 2028. (4 cyanobenzyl bromide) A: 4 Cyanobenzyl bromide is often used as an alkylating agent to introduce the 4-cyanobenzyl group into molecules. It is also employed in nucleophilic substitution reactions and can react with phosphonium salts like methyl or butyl triphenylphosphonium bromide for Wittig reactions. A: Both are phosphonium salts used in Wittig reactions, but methyl triphenylphosphonium bromide generates shorter alkene chains, while butyl triphenylphosphonium bromide produces longer-chain alkenes. The alkyl chain length determines the final product structure. A: Yes, 4 cyanobenzyl bromide can react with triphenylphosphonium salts (e.g., methyl or butyl) to form ylides for Wittig olefination. This enables the synthesis of substituted alkenes with a cyanobenzyl group. A: Use gloves and eye protection due to its lachrymatory and irritant properties. Work in a fume hood to avoid inhalation, and store separately from strong bases to prevent decomposition. A: No—the choice determines the alkene product. Methyl triphenylphosphonium bromide yields methyl-substituted alkenes, while butyl variants produce butyl-substituted ones. Select based on the desired carbon chain length.
Understanding the Role of 4 Cyanobenzyl Bromide in Modern Synthesis
Technical Advantages in Synthesis and Catalysis
Parameter
4 Cyanobenzyl Bromide
MTPB
BTPB
Purity Grade
≥99.5%
≥98%
Reaction Temp Range
-20°C to 150°C
0°C to 180°C
-10°C to 200°C
Catalytic Efficiency
N/A
83%
78%
Performance Comparison: Key Manufacturers
Supplier
Purity (%)
Price/kg (USD)
Lead Time
Supplier A
99.7
420
2 weeks
Supplier B
99.2
385
3 weeks
Supplier C
98.8
360
4 weeks
Customized Solutions for Diverse Industrial Needs
Case Studies: Real-World Applications
/MTPB combinations. Process optimization reduced reaction steps from 5 to 3 while maintaining 99.2% HPLC purity.Handling and Safety Protocols
Why 4 Cyanobenzyl Bromide Remains Indispensable
FAQS on 4 cyanobenzyl bromide
Q: What is the common application of 4 cyanobenzyl bromide in organic synthesis?
Q: How does methyl triphenylphosphonium bromide differ from butyl triphenylphosphonium bromide?
Q: Can 4 cyanobenzyl bromide be used with triphenylphosphonium salts in Wittig reactions?
Q: What safety precautions are required when handling 4 cyanobenzyl bromide?
Q: Are methyl and butyl triphenylphosphonium bromide interchangeable in reactions with 4 cyanobenzyl bromide?
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